0309国际期刊速递丨今日热点射血分

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TODAY今日发布BMCCardiovascDisordDec01,:19(1)今日发布01篇（共计54篇）CurrCardiovascRiskRepApr01,:13(4)今日发布01篇（共计02篇）JAHAMar19,:8(6)今日发布07篇（共计11篇）HeartFailRevEarlyRecent,Mar08,今日发布01篇IntJCardiovascImagingEarlyRecent,Mar08,今日发布02篇HerzschrittmachertherElektrophysiolEarlyRecent,Mar08,今日发布01篇CardiovascDrugsTherEarlyRecent,Mar09,今日发布01篇HeartFailRevEarlyRecent,Mar09,今日发布01篇JIntervCardElectrophysiolEarlyRecent,Mar09,今日发布01篇RECOMMEND推荐阅读01蛋白质组学分析和新发房颤的风险：弗雷明翰心脏研究JAHAresearch-articleDaraeKo,MarkD.Benson,etc.1小时前等45用户推荐阅读本文BackgroundPriorstudiesrelatingproteomicsmarkerstoincidentAFscreenedforlimitednumbersofproteins.先前的研究将蛋白质组学标记物与偶发性房颤相关，筛选出有限数量的蛋白质。MethodsandResultsWeperformedproteomicsassaysamongparticipantsfromtheFraminghamHeartStudyOffspringattendingtheirfifthexamination.Plasmaproteinlevels(n=)weremeasuredbytheSOMAscanproteomicprofilingplatform.WeusedrobustinferencefortheCoxproportionalhazardsmodeltorelateeachproteinlevelwithincidentAF.Inaddition,weexaminedtheassociationbetweenAF‐relatedgeneticlociandlevelsofproteinsassociatedwithAF.Ourstudyincludedparticipants(meanage55±10years,54%women)whohadproteomicprofilesmeasured.AtotalofparticipantsdevelopedAFduringfollow‐up(meanfollow‐up18.3years).Weobservedthat8proteinsweresignificantlyassociatedwithincidentAFafteradjustingforage,sex,technicalcovariates,andcorrectionformultipletesting(P0.05/=3.6×10?5).AfteradditionaladjustmentsforclinicalfactorsassociatedwithAF,ADAMTS13andN‐terminalpro‐B‐typenatriureticpeptideremainedsignificantlyassociatedwiththeriskofincidentAF(hazardratio,0.78;95%CI,0.70–0.88;and1.44;95%CI,1.22–1.70,respectively;P3.6×10?5forboth).Noneofthe8proteinswereencodedbygenesatAF‐relatedgeneticlocipreviouslyidentifiedbygenome‐wideassociationstudies.我们对参加第五次检查的弗雷明翰心脏研究后代的参与者进行了蛋白质组学分析。血浆蛋白水平（n=）由Somascan蛋白质组学分析平台测定。我们对Cox比例风险模型进行了强有力的推断，将每种蛋白水平与房颤发生率联系起来。此外，我们还研究了房颤相关基因座与房颤相关蛋白水平之间的关系。我们的研究包括名受试者（平均年龄55±10岁，54%的女性），这些受试者都有蛋白质组学特征。随访期间共有名参与者发生房颤（平均随访18.3年）。我们观察到8种蛋白在校正年龄、性别、技术协变量和多次检测校正后与房颤发生率显著相关（P0.05/=3.6×10-5）。在对与房颤相关的临床因素进行额外调整后，Adamts13和N末端前列腺素B型钠尿肽仍与房颤发生的风险显著相关（风险比分别为0.78、95%可信区间为0.70-0.88和1.44、95%可信区间为1.22-1.70，两者P3.6×10-5）。这8种蛋白质中没有一种是由以前通过全基因组关联研究确定的AF相关基因座的基因编码的。ConclusionsWeidentified8proteinsassociatedwithriskofincidentAFafteradjustmentforageandsex;2proteinswereassociatedwithAFafteradjustmentforAFriskfactors.Futurestudiesareneededtoreplicateourfindings,identifywhetherthemarkersaremechanisticallyrelatedtoAFdevelopment,andwhethertheyareclinicallyusefulforidentificationoffutureAFrisk.我们确定了8种与年龄和性别调整后发生房颤风险相关的蛋白质；2种与房颤风险因素调整后发生房颤相关的蛋白质。未来的研究需要复制我们的发现，确定这些标记物是否与房颤的发生机制相关，以及它们是否在临床上有助于确定未来的房颤风险。扫描

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